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[11C]carfentanil
- Development stage
- Unknown
- Lead developer
- University of Pennsylvania
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
[11C]carfentanil is a radiolabeled version of carfentanil, a highly potent synthetic opioid. It is used as a radiotracer in positron emission tomography (PET) imaging to visualize and quantify mu-opioid receptor (MOR) expression in the brain and body. With a sub-nanomolar affinity (Ki of 0.024 nM) and high selectivity for the mu-opioid receptor, it has been used for decades to study MOR behavior in humans, non-human primates, and rodents. The radiotracer has been instrumental in advancing understanding of MOR pharmacology, pain mechanisms, and various pathological conditions.
- Other names
- [11C]carfentanilcarbon-11 labeled carfentanilcarbon11 labeled carfentanilcarbon 11 labeled carfentanil
02
Targets
MOR (Mu opioid receptor)
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